Recombinant human NRG-1 protein

Catalog Number	OGF020
Price	Online Inquiry

Introduction

Recombinant human NRG-1 protein is a recombinant growth factor designed for in vitro research, widely used in cell culture and organoid-related studies to support cell growth and functional analysis.

Background

Neuregulin-1 (NRG-1) is a member of the neuregulin family (NRG1–4), encoded by a single gene that generates extensive diversity through alternative promoter usage and alternative splicing. Multiple isoforms exist, differing in tissue distribution, receptor specificity, and biological activity.

All NRG-1 isoforms contain an epidermal growth factor (EGF)-like domain responsible for receptor binding. This domain exists in α and β variants, with the β isoform generally exhibiting higher affinity toward ErbB4 receptors. NRG-1 signals through ErbB3 (HER3) and ErbB4 (HER4) receptor tyrosine kinases, triggering downstream PI3K/AKT and MAPK pathways.

NRG-1 is essential for cardiac morphogenesis, neural development, and synaptic function. Dysregulation has been associated with neuropsychiatric disorders and various cancers. In vitro, recombinant NRG-1 is commonly used in stem cell maintenance media and in protocols for cardiac and neuronal differentiation.

Product Information

Species	Human
Formulation	1x PBS, See Certificate of Analysis for details
Organoid Type	Breast organoids
Growth Factor	NRG-1
GeneID	3084
Expression	HEK293
Purity	>95%
Endotoxin	<1 EU/µg
Accession Number	Q02297
Molecular Mass	~44 kDa
Species Reactivity	human species similarity: mouse - 98% rat - 83% bovine - 100% porcine - 100%
Stability and Storage	Lyophilized: Store at −20 °C to −80 °C until expiry date; alternatively, stable at room temperature for up to 2 weeks Reconstituted (per CoA): Stable for up to 6 months at −20 °C to −80 °C, or up to 1 week at 23 °C
Reconstitution	Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.5% endotoxin-free recombinant serum albumin (HSA). Gently swirl or tap vial to mix.
Synonyms	Neuregulin1 (NRG1-β1), Neu differentiation factor (rat), Heregulin, HRG, HRG1-β1, Breast cancer cell differentiation factor p45, ARIA (Acetylcholine, Receptor Inducing Activity), glial growth factor, NRG 1, NRG1, Qk45

For research use only. Not for any other purpose.

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