Predict human drug absorption, metabolism, and bioavailability with advanced organoid and organ-on-a-chip ADME platforms designed to de-risk drug discovery and accelerate candidate selection.
- Introduction
- Platform
- Capabilities
- Workflow
- Features
- Applications
Human-Relevant Platforms for Drug Absorption, Distribution, Metabolism, and Excretion Studies
Reliable ADME (absorption, distribution, metabolism, excretion) data is essential for selecting promising drug candidates and predicting human pharmacokinetics. Traditional 2D cell cultures often fail to capture complex tissue physiology, and animal models may not reflect human metabolism accurately.
Our organoid ADME models and organ-on-chip technologies overcome these limitations. These microphysiological systems (MPS) recreate tissue architecture, cellular heterogeneity, and dynamic microenvironments, enabling more accurate in vitro prediction of drug behavior, metabolism, and interactions.
Our ADME Technology Platform
Human Organoid Platform
3D organoids derived from human tissues replicate cellular organization and metabolic activity, enabling studies of drug absorption, metabolism, and transporter function.
Organ-on-Chip Systems
Microfluidic chips simulate physiological flow, shear stress, and tissue–tissue interactions, improving predictive human ADME modeling.
Multi-Organ-on-Chip Systems
Connected organ models allow simulation of systemic drug disposition, linking absorption, metabolism, and clearance in one platform.
Advanced Bioanalytical & Modeling Tools
Our platform integrates LC–MS/MS quantification, metabolite profiling, and PBPK modeling, translating in vitro data into actionable pharmacokinetic insights.
Comprehensive ADME Assay Capabilities
Drug Absorption
Drug absorption studies evaluate how compounds cross epithelial barriers and enter systemic circulation. We use human intestinal organoids and gut-on-chip systems to model intestinal epithelium structure and transporter expression.
These platforms enable evaluation of:
- intestinal drug absorption potential
- epithelial permeability and transport mechanisms
- transporter-mediated drug uptake
Drug Metabolism
Drug metabolism is primarily assessed using human liver organoids and liver-on-chip models, which exhibit active cytochrome P450 enzyme expression and metabolic activity.
These systems support studies including:
- CYP450-mediated drug metabolism
- metabolic stability assays
- metabolite identification and profiling
Drug Bioavailability
Bioavailability reflects the fraction of an administered drug that reaches systemic circulation. To evaluate this parameter in vitro, we combine gut–liver organ-on-chip systems that simulate the sequence of intestinal absorption followed by hepatic first-pass metabolism.
This integrated approach enables:
- evaluation of first-pass metabolism effects
- prediction of oral drug bioavailability
- assessment of metabolite formation during absorption
Barrier Permeability Assays
Drug candidates must often cross biological barriers before reaching their target tissues. Our platform includes barrier permeability assays using specialized organoid and organ-on-chip models.
Examples include:
- intestinal barrier models for oral drug permeability
- blood–brain barrier (BBB)-on-chip systems for CNS drug penetration studies
- epithelial barrier models for tissue distribution analysis
Drug–Drug Interaction (DDI) Studies
Drug–drug interactions can alter pharmacokinetic behavior and impact clinical safety. Our organoid ADME platform supports early evaluation of DDI risk using human-relevant tissue models.
Key assays include:
- CYP inhibition and induction studies using liver organoids
- transporter-mediated interaction analysis using intestinal models
- integrated metabolism and transport studies using organ-on-chip platforms
Typical Study Workflow
We provide a transparent, standardized workflow for all ADME studies:
Advantages of Our ADME Platform
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Human-Relevant Physiology
Models derived from human tissues replicate structural and functional features of native organs. -
Enhanced Predictive Power
Microphysiological systems provide a more accurate representation of drug exposure and tissue response than 2D cultures or animal models. -
Integrated ADME Evaluation
Multi-organ platforms enable simultaneous assessment of absorption, metabolism, clearance, and drug interactions. -
Scalable and Reproducible Systems
Standardized organoid production ensures consistent results across studies. -
High-Throughput Compatibility
Suitable for hit identification, lead optimization, and candidate selection, supporting faster decision-making.
Applications in Drug Discovery
Our ADME CRO services are applicable across multiple stages:
- Hit identification and compound screening
- Lead optimization and structure–metabolism studies
- Candidate selection based on human-relevant PK data
- Drug–drug interaction assessment
- Mechanistic studies of absorption, metabolism, and clearance
Start Your ADME study with human-relevant models
Our team of scientists provides customized study design and consultation.
Discuss your project today or submit a compound for evaluation.
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