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Organoids follow intrinsic developmental procedures and develop from self-organized stem cells to reproduce the key structural and functional characteristics of their in vivo counterparts. The similarities of organoids to actual organs make them more attractive for target identification and verification early in drug development.
Organ-on-a-chip technology relies on our understanding of human organs to construct man-made structures in which cells and their microenvironment are precisely controlled. Due to better reproducibility and controllability, organ-on-a-chip are more suitable for efficacy and safety screening.