Choroid Plexus Organoid Differentiation Kit
| Catalog Number | OCM021 |
| Price | Online Inquiry |
Introduction
A system for generating choroid plexus organoids from human pluripotent stem cells for neural biomarker discovery and central nervous system permeability studies. These organoids model the blood-cerebrospinal fluid barrier with three-dimensional tissue structure and functional epithelium, providing controlled access for drug distribution studies and cerebrospinal fluid production research. Based on award-winning published protocols recognized for advances in animal reduction and replacement, the five-stage protocol includes embryoid body formation, neuroepithelial expansion, and patterning to choroid plexus-like epithelium. Mature organoids feature cystic structures filled with cerebrospinal fluid-like fluid surrounded by epithelium expressing choroid plexus-specific markers. Maturation components are available separately for extended culture beyond 40 days.
Application
Cell Culture, Differentiation, Functional Assay, Organoid Culture, Phenotyping, Toxicity Assay
Feature
Creates a unique in vitro model of the blood-CSF barrier for targeted discovery of CNS-specific biomarkers and analysis of secretory function.
Product Information
| Species | Human |
| Formulation | Serum-Free |
| Cell Type | Epithelial Cells, PSC-Derived, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells |
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